CCL22

CCL22

quimioquina (C-C motif) ligando 22
Identificadores
Símbolo CCL22
Símbolos alt. SCYA22, MDC, STCP-1, ABCD-1, DC/B-CK, A-152E5.1, MGC34554
Entrez 6367
HUGO 10621
OMIM 602957
RefSeq NM_002990
UniProt O00626
Otros datos
Locus Cr. 16 q13

La Quimioquina (C-C motif) ligando 22 (CCL22) es una pequeña citoquina perteneciente a la familia CC de quimioquinas, que es conocida también bajo otros diversos nombres, que incluyen llos de quimioquina macrófago-derivada (MDC) y proteína quimiotáctica de células T estimuladas (STCP-1). Se trata de un quimioatrayente para células T, monocitos, células dendríticas derivadas de monocitos, y células NK activadas.[1] [2] CCL22 es secretada por células dendríticas y macrófagos, y obtiene su efecto en sus células diana mediante la interacción con receptores de quimioquinas en la superficie celular, como el receptor CCR4.[3] [4] El gen que codifica para CCL22 se localiza en el cromosoma 16 en humanos, en un cluster con otras quimioquinas llamadas CX3CL1 y CCL17.[5] [6]

Referencias

  1. Godiska et al. Human macrophage-derived chemokine (MDC), a novel chemoattractant for monocytes, monocyte-derived dendritic cells, and natural killer cells. J. Exp. Med. 185:1595-1604 (1997).
  2. Chang et al. Molecular cloning and functional characterization of a novel CC chemokine, stimulated T cell chemotactic protein (STCP-1) that specifically acts on activated T lymphocytes. J. Biol. Chem. 272:25229-25237 (1997).
  3. Vulcano et al. Dendritic cells as a major source of macrophage-derived chemokine/CCL22 in vitro and in vivo. Eur. J. Immunol. 31:812-822 (2001).
  4. Imai et al. Macrophage-derived chemokine is a functional ligand for the CC chemokine receptor 4. J. Biol. Chem. 273:1764-1768 (1998).
  5. Loftus et al. Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. Genomics 60:295-308 (1999).
  6. Nomiyama et al. Human chemokines fractalkine (SCYD1), MDC (SCYA22) and TARC (SCYA17) are clustered on chromosome 16q13. Cytogenet. Cell Genet. 81: 10-11 (1998).
Obtenido de "CCL22"

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Mira otros diccionarios:

  • CCL22 — Chemokine (C C motif) ligand 22, also known as CCL22, is a human gene.cite web | title = Entrez Gene: CCL22 chemokine (C C motif) ligand 22| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=6367| accessdate …   Wikipedia

  • Chemokine — Small cytokines (intecrine/chemokine), interleukin 8 like Solution structure of interleukin 8, a chemokine of the CXC subfamily Identifiers Symbol IL8 …   Wikipedia

  • CX3CL1 — Chemokine (C X3 C motif) ligand 1 PDB rendering based on 1b2t …   Wikipedia

  • Chemokin — Dreidimensionale Struktur des Chemokins Interleukin 8 (CXCL8) in seiner dimeren Form Chemokine (Name abgeleitet aus chemotaktische Zytokine), sind eine Gruppe der Zytokine, also kleine Signalproteine, die bei Zellen eine Wanderungsbewegung… …   Deutsch Wikipedia

  • Chemokine — Dreidimensionale Struktur des Chemokins Interleukin 8 (CXCL8) in seiner dimeren Form Chemokine (Name abgeleitet aus chemotaktische Zytokine), sind eine Gruppe der Zytokine, also kleine Signalproteine, die bei Zellen eine Wanderungsbewegung… …   Deutsch Wikipedia

  • Fraktalkin — Dreidimensionale Struktur des Chemokins Interleukin 8 (CXCL8) in seiner dimeren Form Chemokine (Name abgeleitet aus chemotaktische Zytokine), sind eine Gruppe der Zytokine, also kleine Signalproteine, die bei Zellen eine Wanderungsbewegung… …   Deutsch Wikipedia

  • Fraktalkine — Dreidimensionale Struktur des Chemokins Interleukin 8 (CXCL8) in seiner dimeren Form Chemokine (Name abgeleitet aus chemotaktische Zytokine), sind eine Gruppe der Zytokine, also kleine Signalproteine, die bei Zellen eine Wanderungsbewegung… …   Deutsch Wikipedia

  • Haematopoiesis — Diagram showing the development of different blood cells from haematopoietic stem cell to mature cells Haematopoiesis (from Ancient Greek: αἷμα, blood ; ποιεῖν to make ) (or hematopoiesis in the United States; sometimes also haemopoiesis or… …   Wikipedia

  • Cytokine — Cytokines (Greek cyto , cell; and kinos, movement) are small cell signaling protein molecules that are secreted by the glial cells of the nervous system and by numerous cells of the immune system and are a category of signaling molecules used… …   Wikipedia

  • MDC — usually refers to: Movement for Democratic Change – Tsvangirai (MDC T), a Zimbabwean political party Movement for Democratic Change (pre 2005), a former Zimbabwean political party that split in 2005 into the MDC T and MDC M Movement for… …   Wikipedia


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